Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• systems. Metal NPs can lead to greater signal amplification, greater sensitivity, and higher detection. However, NPs with properties that generate ROS can increase cell damage. In cancer cells, rapid proliferation leads to an imbalance of oxygen, abnormal structure, and blood supply, making the tumor

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• . However, this conventional LFA technique based on colorimetric analysis is neither useful to determine critical analytes with desired sensitivity, nor can it quantify the analytes. Various signal amplification strategies have been proposed to improve the sensitivity and the quantitative determination of

• advances in photothermal LFAs and their application in detecting analytes. Keywords: lateral flow assay; nanoarchitectonics; photothermal; photothermal nanomaterials; signal amplification; Introduction Lateral flow assays (LFAs) are a versatile and convenient point-of-care testing (POCT) technique used

• “yes” or “no” answer, and more sophisticated tests are required to validate the results [6]. Additionally, LFAs suffer from limitations such as lack of quantitative determination of analytes and appropriate signal amplification techniques to see the test line at very low concentrations of analytes

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• -cdse/ZnS quantum dots. This type of tracer has a significant signal amplification effect. Vesicle composite probes were generated using aptamer-labeled SSB/L-QD and nanogold (Au-Apt). Since Au-aptas receptors burst the signal of SSB/L-QD, this type of probe cannot fluoresce "off". To solve this problem

• vesicle probes have a strong signal amplification ability. More quantum dots can be labeled within the double phosphorus lipid membrane. The detection process is straightforward and does not require pretreatment. The fluorescence signal can be easily switched from "off" to "on" after the target is added

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• sensor can approach F-sub, and then F-sub cutting and fluorescence signal amplification are carried out in the presence of analytes. Bakshi et al. proposed a cellular nanoreactor. It had two kinds of magnetic particles, each of which is functionalized by two components of the binary deoxyribozyme system

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• target with a probe followed by the direct naked-eye readout. The need for further improvements motivated the researchers to increases the complexity of the assays. Today, the methods for SNP detection can be classified as enzymatic and nonenzymatic. In enzyme-free strategies, the signal amplification is

• cyclically amplify the process of DNA self-assembly. The strategies based on enzymatic tools, on the other hand, are characterized by an extraordinary potential for signal amplification. The main advantages of using enzymes involve: a) the capability of modifying oligonucleotides (e.g., polymerases

• discrimination of DNA mutations in complex physiological media. To implement enzymes into assays for single-nucleotide discrimination using gold nanoparticles as signal transducers, exonuclease-assisted signal amplification (EASA) is commonly used. By coupling cyclic enzymatic cleavage and signal amplification

Fabrication of silver nanoisland films by pulsed laser deposition for surface-enhanced Raman spectroscopy

• Bogusław Budner,
• Mariusz Kuźma,
• Barbara Nasiłowska,
• Bartosz Bartosewicz,
• Malwina Liszewska and
• Bartłomiej J. Jankiewicz

Beilstein J. Nanotechnol. 2019, 10, 882–893, doi:10.3762/bjnano.10.89

• maps consisting of 351 points per sample. Based on them the average spectrum was obtained and the standard deviation of the signal was determined, which is an indicator of the homogeneity of the deposited layers and Raman signal amplification obtained. Statistical analysis of the intensity of the

• recorded spectra and their standard deviation were made for the 1080 cm−1 peak. The average intensity of the peak calculated based on 351 measurement points and the standard deviation of the intensity allow us to determine which samples have the highest Raman signal amplification and highest homogeneity of

Bidirectional biomimetic flow sensing with antiparallel and curved artificial hair sensors

• Claudio Abels,
• Antonio Qualtieri,
• Toni Lober,
• Alessandro Mariotti,
• Lily D. Chambers,
• Massimo De Vittorio,
• William M. Megill and
• Francesco Rizzi

Beilstein J. Nanotechnol. 2019, 10, 32–46, doi:10.3762/bjnano.10.4

• temperature decrease influenced the offset voltage for the single cantilever sensor. In the subsequent warming up phase (data not shown), the output dropped back to its offset voltage (7.22 V). Accommodating for signal amplification, the actual drift was 1 mV. The temperature experiments were repeated for the

• . Due to variation in the resistances (see Table 3), the half-bridge circuit was not perfectly balanced and a drift of 15 mV was measured. Accommodating for signal amplification, the actual drift was 0.15 mV. The artificial hair sensors did not generate heat, which suggests that they changed their

Low cost tips for tip-enhanced Raman spectroscopy fabricated by two-step electrochemical etching of 125 µm diameter gold wires

• Antonino Foti,
• Francesco Barreca,
• Enza Fazio,
• Cristiano D’Andrea,
• Paolo Matteini,
• Onofrio Maria Maragò and
• Pietro Giuseppe Gucciardi

Beilstein J. Nanotechnol. 2018, 9, 2718–2729, doi:10.3762/bjnano.9.254

• tip is the key element in TERS. Its field enhancement and confinement capabilities determine the signal amplification, the spatial resolution and the reproducibility of the results. The material, morphology, aspect ratio and size of the tip apex are expected to determine the optical properties of the

Fabrication of gold-coated PDMS surfaces with arrayed triangular micro/nanopyramids for use as SERS substrates

• Jingran Zhang,
• Yongda Yan,
• Peng Miao and
• Jianxiong Cai

Beilstein J. Nanotechnol. 2017, 8, 2271–2282, doi:10.3762/bjnano.8.227

• ][10]. As compared to traditional Raman scattering technology, SERS can provide significant signal amplification for analyte molecules absorbed on a SERS-active substrate and can extend the scope of Raman scattering to detect molecules at very low concentrations. Metals such as gold, silver and copper

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

• Christa Genslein,
• Peter Hausler,
• Eva-Maria Kirchner,
• Rudolf Bierl,
• Antje J. Baeumner and
• Thomas Hirsch

Beilstein J. Nanotechnol. 2016, 7, 1564–1573, doi:10.3762/bjnano.7.150

• continuous gold films, gold nanohole arrays can significantly improve the performance of SPR devices in angle-dependent measurement mode, as a signal amplification arises from localized surface plasmons at the nanostructures. This leads consequently to an increased sensing capability of molecules bound to

Understanding interferometry for micro-cantilever displacement detection

• Alexander von Schmidsfeld,
• Tobias Nörenberg,
• Matthias Temmen and
• Michael Reichling

Beilstein J. Nanotechnol. 2016, 7, 841–851, doi:10.3762/bjnano.7.76

• cavity of a Fabry–Pérot interferometer yields high optical signal amplification but requires a sophisticated cavity design or active stabilization [29][30][31]. Here, we described an interferometer with a strongly asymmetric low-finesse cavity combining the high reflectivity of a metal-coated cantilever

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• – very small size, high loading of signal tags, high surface area and dynamic character for signal amplification [6]. Some types of nanomaterials have been self-assembled into vesicle structures for different purposes. Béalle et al. [7] describe the use of super-paramagnetic iron oxide nanoparticles to

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• microdisc resonators, was readily detectable through changes in the effective refractive index of the waveguide setup and the concomitant shifts in the resonant wavelength of the sensor cavity, with signal amplification through label-free enzyme-linked immunosorbent assay (ELISA) [134]. The sensor system

Electrochemical behavior of polypyrrol/AuNP composites deposited by different electrochemical methods: sensing properties towards catechol

• Celia García-Hernández,
• Cristina García-Cabezón,
• Cristina Medina-Plaza,
• Fernando Martín-Pedrosa,
• Yolanda Blanco,
• José Antonio de Saja and
• María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2015, 6, 2052–2061, doi:10.3762/bjnano.6.209

• Once stable Ppy/AuNP electrodes were obtained, their electrocatalytic and sensing properties towards catechol (a phenolic compound of interest in the food industry), were analyzed in terms of signal amplification and peak shifts. Experiments were carried out in the range between −0.1 and 0.8 V at a

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• particularly anticipated in the fields of electrochemical sensors and biosensors, where Au nanoparticles play a fundamental role as labels or platforms for immobilization. In this respect, our results suggest that enhanced signal amplification and increased magnetic separation efficiency are likely. In

Superluminescence from an optically pumped molecular tunneling junction by injection of plasmon induced hot electrons

• Kai Braun,
• Xiao Wang,
• Andreas M. Kern,
• Hilmar Adler,
• Heiko Peisert,
• Thomas Chassé,
• Dai Zhang and
• Alfred J. Meixner

Beilstein J. Nanotechnol. 2015, 6, 1100–1106, doi:10.3762/bjnano.6.111

• Information File 1), leading to a spectral narrowing of the luminescence of about 40% to 55 nm. Such a spectral narrowing along with the nonlinear intensity increase observed as a function of optical pump power is a reliable sign of signal amplification by positive feedback. This feedback directs a portion of

Localized surface plasmon resonances in nanostructures to enhance nonlinear vibrational spectroscopies: towards an astonishing molecular sensitivity

• Dan Lis and
• Francesca Cecchet

Beilstein J. Nanotechnol. 2014, 5, 2275–2292, doi:10.3762/bjnano.5.237

• remarkable sensitivity of SFG given that the intensity scale with N2. Also, thanks to this signal amplification, Humbert et al. succeeded to obtain the SFG signature of thiophenol in the fingerprint spectral range (ring deformation vibrations), where nonlinear activities are intrinsically rather weak. This

Control theory for scanning probe microscopy revisited

• Julian Stirling

Beilstein J. Nanotechnol. 2014, 5, 337–345, doi:10.3762/bjnano.5.38

• replacing the operator , with an operator that describes the tip–sample interaction and signal amplification of the SPM to be modelled. The feedback response of an SPM, without the inclusion of mechanical resonances, calculated for four different topographies, and for a range of feedback gains. Topographies

The morphology of silver nanoparticles prepared by enzyme-induced reduction

• Henrik Schneidewind,
• Thomas Schüler,
• Katharina K. Strelau,
• Karina Weber,
• Dana Cialla,
• Marco Diegel,
• Roland Mattheis,
• Andreas Berger,
• Robert Möller and
• Jürgen Popp

Beilstein J. Nanotechnol. 2012, 3, 404–414, doi:10.3762/bjnano.3.47

• the first layer next to the silver nanoparticles undergo the most efficient signal amplification. The simplest approach for quantitative investigations may be to carry out SERS measurements of solutions only in such concentration ranges, in which all binding sites of the SERS substrate are saturated

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• generation and AD604 for NMR signal amplification; Analog Devices) and off-the-shelf RF components (e.g., ZAD-1 mixer, ZMSC-2 power splitter, and ZYSWA-2 RF switch; Mini-Circuits) [14]. In newer versions, these functionalities have been integrated onto a single CMOS IC chip [17][19]. This chip was designed